Oxime-Based Carbonates as Useful Reagents for Both N-Protection and Peptide Coupling

Molecules

Yahya El-Sayed Jad¹  Sherine N. Khattab¹  Ayman El-Faham¹ 

[1] ¹Department of Chemistry, Faculty of Science, Alexandria University, P.O. Box 426, Ibrahimia, 21321 Alexandria, Egypt

关键词: oxime;    additives;    N-protection;    activation;    coupling;    peptide;   

DOI  :  10.3390/molecules171214361

来源: mdpi

【 摘 要 】

We have demonstrated that oxime-based mixed carbonates are very effective reagents for both N-protection and peptide coupling.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.