The Pneumonia Virus of Mice (PVM) Model of Acute Respiratory Infection

Viruses

Kimberly D. Dyer¹  Katia E. Garcia-Crespo¹  Stephanie Glineur¹  Joseph B. Domachowske² 

[1] Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA; E-Mails:;Department of Pediatrics, SUNY Upstate Medical University, Syracuse, NY 13210, USA; E-Mail:

关键词: PVM;    inflammation;    leukocytes;    eosinophils;    respiratory syncytial virus;    RSV;    TLR;    IFN;    heterologous immunity;    MIP-1α;   

DOI  :  10.3390/v4123494

来源: mdpi

【 摘 要 】

Pneumonia Virus of Mice (PVM) is related to the human and bovine respiratory syncytial virus (RSV) pathogens, and has been used to study respiratory virus replication and the ensuing inflammatory response as a component of a natural host—pathogen relationship. As such, PVM infection in mice reproduces many of the clinical and pathologic features of the more severe forms of RSV infection in human infants. Here we review some of the most recent findings on the basic biology of PVM infection and its use as a model of disease, most notably for explorations of virus infection and allergic airways disease, for vaccine evaluation, and for the development of immunomodulatory strategies for acute respiratory virus infection.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.