Hydroxysafflor Yellow A (HSYA) from Flowers ofCarthamus tinctorius L. and Its Vasodilatation Effects on Pulmonary Artery

Molecules

Yuhua Bai¹  Ping Lu¹  Chenghua Han¹  Chunyue Yu¹  Minggang Chen¹  Fa He¹  Dan Yi¹ 

[1] ¹College of Pharmacy, Harbin Medical University, Harbin 150081, Heilongjiang, China ²College of Pharmacy, Harbin Medical University-Daqing, Daqing 163319, Heilongjiang, China ^†These authors contributed equally to this work.

关键词: HSYA;    Carthamus tinctorius L.;    pulmonary arteries;    vasodilatation;   

DOI  :  10.3390/molecules171214918

来源: mdpi

【 摘 要 】

Flowers of Carthamus tinctorius L. are traditionally used in China to treat cerebrovascular and cardiovascular diseases. Hydroxysafflor yellow A (HSYA), the main constituent of Carthamus tinctorius L. flowers, is known for its multiple biological activities. In the present study, HSYA was isolated from Carthamus tinctorius L. flowers by a macroporous resin adsorption chromatography method coupled with a Waters high-throughput auto-purification system and it's vasodilatation effects on pulmonary artery (PA) were explored by an assay of tension study on rat pulmonary artery (PA) rings. Results suggest that HSYA possesses vascular relaxation effects on rat PA by activating the KV channel in pulmonary vascular smooth muscle cells (PVSMCs).

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.