Sesquiterpene and Acetogenin Derivatives from the Marine Red Alga Laurencia okamurai

Marine Drugs

Yi Liang¹  Xiao-Ming Li¹  Chuan-Ming Cui¹  Chun-Shun Li¹  Hong Sun¹ 

[1] Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China;

关键词: marine alga;    Laurencia okamurai;    bisabolane sesquiterpene;    C₁₂-acetogenin;    brine shrimp lethality;   

DOI  :  10.3390/md10122817

来源: mdpi

【 摘 要 】

In addition to 13 known compounds, four new bisabolane sesquiterpenes, okamurenes A–D (1–4), a new chamigrane derivative, okamurene E (5), and a new C₁₂-acetogenin, okamuragenin (6), were isolated from the marine red alga Laurencia okamurai. The structures of these compounds were determined through detailed spectroscopic analyses. Of these, okamurenes A and B (1 and 2) are the first examples of bromobisabolane sesquiterpenes possessing a phenyl moiety among Laurencia-derived sesquiterpenes, while okamuragenin (6) was the first acetogenin aldehyde possessing a C₁₂-carbon skeleton. Each of the isolated compounds was evaluated for the brine shrimp (Artemia salina) lethal assay and 7-hydroxylaurene displayed potent lethality with LD₅₀ 1.8 μM.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.