Substrate Effects on the Formation Process, Structure and Physicochemical Properties of Supported Lipid Bilayers

Materials

关键词: lipid bilayer membranes;    silicon oxide;    mica;    titanium dioxide;    atomic force microscope;    fluorescence microscope;    single molecule tracking;    surface hydrophilicity;    anomalous diffusion;    phase separation;   

DOI  :  10.3390/ma5122658

来源: mdpi

【 摘 要 】

Supported lipid bilayers are artificial lipid bilayer membranes existing at the interface between solid substrates and aqueous solution. Surface structures and properties of the solid substrates affect the formation process, fluidity, two-dimensional structure and chemical activity of supported lipid bilayers, through the 1–2 nm thick water layer between the substrate and bilayer membrane. Even on SiO₂/Si and mica surfaces, which are flat and biologically inert, and most widely used as the substrates for the supported lipid bilayers, cause differences in the structure and properties of the supported membranes. In this review, I summarize several examples of the effects of substrate structures and properties on an atomic and nanometer scales on the solid-supported lipid bilayers, including our recent reports.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.