Synthesis and Antiradical/Antioxidant Activities of Caffeic Acid Phenethyl Ester and Its Related Propionic, Acetic, and Benzoic Acid Analoguesc

Molecules

Luc M. LeBlanc¹  Aurélie F. Paré¹  Jacques Jean-François¹  Martin J. G. Hébert¹  Marc E. Surette¹ 

[1] Department of Chemistry and Biochemistry, Université de Moncton, Moncton, NB E1A 3E9, Canada

关键词: CAPE;    caffeic acid;    3-(3;    4-dihydroxyphenyl) propanoic acid esters;    2-(3;    4-dihydroxyphenyl) acetic acid esters;    3;    4-dihydroxybenzoic acid esters;    antioxidant;   

DOI  :  10.3390/molecules171214637

来源: mdpi

【 摘 要 】

Caffeic acid phenethyl ester (CAPE) is a bioactive component isolated from propolis. A series of CAPE analogues was synthesized and their antiradical/antioxidant effects analyzed. The effect of the presence of the double bond and of the conjugated system on the antioxidant effect is evaluated with the analogues obtained from 3-(3,4-dihydroxyphenyl) propanoic acid. Those obtained from 2-(3,4-dihydroxyphenyl) acetic acid and 3,4-dihydroxybenzoic acid allow the evaluation of the effect of the presence of two carbons between the carbonyl and aromatic system.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.