Endocytic Pathways Involved in Filovirus Entry: Advances, Implications and Future Directions

Viruses

Suchita Bhattacharyya²  Nirupama Mulherkar¹ 

[1] Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA; E-Mail:;Department of Atomic Energy-Centre for Excellence in Basic Sciences, University of Mumbai, Health Centre Building, Vidyanagari, Kalina, Santacruz East, Mumbai 400098, India; E-Mail:

关键词: filoviruses;    viral entry;    viral internalization;    endocytosis;    endocytic pathways;    clathrin-mediated endocytosis;    macropinocytosis;    caveolae-mediated endocytosis;   

DOI  :  10.3390/v4123647

来源: mdpi

【 摘 要 】

Detailed knowledge of the host-virus interactions that accompany filovirus entry into cells is expected to identify determinants of viral virulence and host range, and to yield targets for the development of antiviral therapeutics. While it is generally agreed that filovirus entry into the host cytoplasm requires viral internalization into acidic endosomal compartments and proteolytic cleavage of the envelope glycoprotein by endo/lysosomal cysteine proteases, our understanding of the specific endocytic pathways co-opted by filoviruses remains limited. This review addresses the current knowledge on cellular endocytic pathways implicated in filovirus entry, highlights the consensus as well as controversies, and discusses important remaining questions.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.