Prototypes of Newly Conceived Inorganic and Biological Sensors for Health and Environmental Applications

Sensors

Claudio Nicolini²  Manuela Adami¹  Marco Sartore¹  Nicola Luigi Bragazzi²  Valter Bavastrello²  Rosanna Spera² 

[1] Elbatech Srl, Marciana, Marciana 57030, Italy; E-Mails:;Laboratories of Biophysics and Nanobiotechnology, Department of Experimental Medicine (DIMES), University of Genoa, Genoa 16132, Italy; E-Mails:

关键词: QCM_D;    protein-protein interaction;    calcium oxide matrices;    CO₂;    Langmuir-Blodgett;    laccase;    amperometry;    clomipramine;   

DOI  :  10.3390/s121217112

来源: mdpi

【 摘 要 】

This paper describes the optimal implementation of three newly conceived sensors for both health and environmental applications, utilizing a wide range of detection methods and complex nanocomposites. The first one is inorganic and based on matrices of calcium oxide, the second is based on protein arrays and a third one is based on Langmuir-Blodgett laccase multi-layers. Special attention was paid to detecting substances significant to the environment (such as carbon dioxide) and medicine (drug administration, cancer diagnosis and prognosis) by means of amperometric, quartz crystal microbalance with frequency (QCM_F) and quartz crystal microbalance with dissipation monitoring (QCM_D) technologies. The resulting three implemented nanosensors are described here along with proofs of principle and their corresponding applications.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland