Immune Responses to West Nile Virus Infection in the Central Nervous System

Viruses

Hyelim Cho¹ 

[1] Departments of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA; E-Mail:

关键词: flavivirus;    innate immunity;    adaptive immunity;    pathogenesis;    immunopathogenesis;    neuron;    brain;   

DOI  :  10.3390/v4123812

来源: mdpi

【 摘 要 】

West Nile virus (WNV) continues to cause outbreaks of severe neuroinvasive disease in humans and other vertebrate animals in the United States, Europe, and other regions of the world. This review discusses our understanding of the interactions between virus and host that occur in the central nervous system (CNS), the outcome of which can be protection, viral pathogenesis, or immunopathogenesis. We will focus on defining the current state of knowledge of WNV entry, tropism, and host immune response in the CNS, all of which affect the balance between injury and successful clearance.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.