An N-Linked Bidentate Phosphoramidite Ligand (N-Me-BIPAM) for Rhodium-Catalyzed Asymmetric 1,4-Addition of Arylboronic Acids to α,β-Unsaturated Ketones

Molecules

Yasunori Yamamoto¹  Kazunori Kurihara¹  Yoshinori Takahashi¹ 

[1] Frontier Chemistry Center, Faculty of Engineering, Hokkaido University, Sapporo 060-8628, Japan

关键词: asymmetric conjugate addition;    rhodium catalyst;    bidentate phosphoramidite ligand;   

DOI  :  10.3390/molecules18010014

来源: mdpi

【 摘 要 】

A new bidentate phosphoramidite (N-Me-BIPAM) based on Shibasaki’s N-linked BINOL was synthesized. This ligand appears to be highly effective for rhodium-catalyzed asymmetric conjugated addition of arylboronic acids to α,β-unsaturated enones. The reaction of ortho-substituted arylboronic acid with acyclic and cyclic enones provides the corresponding products in good yields and enantioselectivities.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.