In Vitro and in Vivo Anticancer Activity of Aconitine on Melanoma Cell Line B16

Molecules

Juan Du¹  Xiaonian Lu¹  Ziwen Long¹  Zhen Zhang¹  Xiaohua Zhu¹  Yongsheng Yang¹ 

[1] ¹Dermatology Department, Huashan Hospital, Fudan University, Shanghai 200040, China ²Shanghai Cancer Center, Fudan University, Shanghai 200040, China ^†These authors contributed equally to this work.

关键词: melanoma;    B16;    aconitine;    apoptosis;    PI3K/AKT;    MAPK/ERK1/2;   

DOI  :  10.3390/molecules18010757

来源: mdpi

【 摘 要 】

The anti-tumor effect of aconitine in melanoma cell line B16 has been studied in this paper. We found that B16 cells showed significantly reduced growth rates and increased apoptotic effects in the presence of aconitine. Furthermore, aconitine inhibited the PI3K/AKT and MAPK/ERK1/2 signaling pathways, thus regulating the levels of protein and mRNA of PCNA and apoptotic related signaling molecules. Above all, we found that aconitine showed an anti-melanoma effect in suppressing tumor growth in vivo. In conclusion, we show that aconitine may be a useful anticancer drug in the future.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.