Soft Coral-Derived Lemnalol Alleviates Monosodium Urate-Induced Gouty Arthritis in Rats by Inhibiting Leukocyte Infiltration and iNOS, COX-2 and c-Fos Protein Expression

Marine Drugs

Hsin-Pai Lee³  Shi-Ying Huang³  Yen-You Lin³  Hui-Min Wang²  Yen-Hsuan Jean⁴  Shu-Fen Wu¹  Chang-Yih Duh³ 

[1] Department of Life Science, Institute of Molecular Biology, National Chung-Cheng University, Chia-Yi 62102, Taiwan; E-Mail:;Department of Fragrance and Cosmetic Science, Center of Excellence for Environmental Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan; E-Mail:;Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 80424, Taiwan; E-Mails:;Department of Orthopaedic Surgery, Ping-Tung Christian Hospital, 60, Ta-Lian Road, Ping-Tung 90059, Taiwan; E-Mail:

关键词: gout;    lemnalol;    monosodium urate;    allodynia;    inflammation;   

DOI  :  10.3390/md11010099

来源: mdpi

【 摘 要 】

An acute gout attack manifests in the joint as dramatic inflammation. To date, the clinical use of medicinal agents has typically led to undesirable side effects. Numerous efforts have failed to create an effective and safe agent for the treatment of gout. Lemnalol—an extract from Formosan soft coral—has documented anti-inflammatory and anti-nociceptive properties. In the present study, we attempt to examine the therapeutic effects of lemnalol on intra-articular monosodium urate (MSU)-induced gouty arthritis in rats. In the present study, we found that treatment with lemnalol (intramuscular [im]), but not colchicine (oral [po]), significantly attenuated MUS-induced mechanical allodynia, paw edema and knee swelling. Histomorphometric and immunohistochemistry analysis revealed that MSU-induced inflammatory cell infiltration, as well as the elevated expression of c-Fos and pro-inflammatory proteins (inducible nitric oxide synthase and cyclooxygenase-2) observed in synovial tissue, were significantly inhibited by treatment with lemnalol. We conclude that lemnalol may be a promising candidate for the development of a new treatment for gout and other acute neutrophil-driven inflammatory diseases.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.