International Journal of Molecular Sciences | |
The Controversial Role of Retinoic Acid in Fibrotic Diseases: Analysis of Involved Signaling Pathways | |
Tian-Biao Zhou1  Gregor P. C. Drummen2  | |
[1] Department of Pediatric Nephrology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China; E-Mail:;Cellular Stress and Ageing Program, Bionanoscience and Bio-Imaging Program, Bio & Nano-Solutions, Helmutstr. 3A, Düsseldorf 40472, Germany; E-Mail: | |
关键词: fibrotic disease; fibrosis; retinoic acid; extracellular matrix; signaling pathways; | |
DOI : 10.3390/ijms14010226 | |
来源: mdpi | |
【 摘 要 】
Fibrotic diseases, such as liver, pulmonary and renal fibrosis, are common end-stage conditions and represent a major global health problem. Furthermore, effective therapeutic measures are presently unavailable. Extracellular matrix accumulation is the most prominent characteristic in the pathogenesis of fibrotic disease. Retinoic acid, including all-
【 授权许可】
CC BY
© 2013 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.
【 预 览 】
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