Suzuki-Miyaura Cross-Coupling in Acylation Reactions,Scope and Recent Developments

Molecules

Marco Blangetti¹  Heléna Rosso¹  Cristina Prandi¹  Annamaria Deagostino¹ 

[1] ¹Centre for Synthesis and Chemical Biology, School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland ²Chemistry Department, Turin University, via P. Giuria 7, 10125 Torino, Italy

关键词: Suzuki-Miyaura cross-coupling;    acylation;    palladium;    ketones;   

DOI  :  10.3390/molecules18011188

来源: mdpi

【 摘 要 】

Since the first report and due to its handiness and wide scope, the Suzuki-Miyaura (SM) cross coupling reaction has become a routine methodology in many laboratories worldwide. With respect to other common transition metal catalyzed cross couplings, the SM reaction has been so far less exploited as a tool to introduce an acyl function into a specific substrate. In this review, the various approaches found in the literature will be considered, starting from the direct SM acylative coupling to the recent developments of cross coupling between boronates and acyl chlorides or anhydrides. Special attention will be dedicated to the use of masked acyl boronates, alkoxy styryl and alkoxy dienyl boronates as coupling partners. A final section will be then focused on the acyl SM reaction as key synthetic step in the framework of natural products synthesis.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.