Design and in Vitro Biocompatibility of a Novel Ocular Drug Delivery Device

Journal of Functional Biomaterials

Nathan Gooch¹  Randon Michael Burr⁴  Dolly J. Holt²  Bruce Gale³ 

[1] Department of Bioengineering, University of Utah, Salt Lake City, UT 84112, USA;Department of Cardiothoracic Surgery, University of Utah, Salt Lake City, UT 84112, USA; E-Mail:;Department of Mechanical Engineering, University of Utah, Salt Lake City, UT 84112, USA; E-Mail:;Moran Eye Center, University of Utah, Salt Lake City, UT 84132, USA; E-Mails:

关键词: CDR;    capsular bag;    drug delivery;    biocompatibility;   

DOI  :  10.3390/jfb4010014

来源: mdpi

【 摘 要 】

The capsule drug ring (CDR) is a reservoir and delivery agent, which is designed to be placed within the capsular bag during cataract surgery. Prototypes were manufactured by hot melt extrusion of Bionate II^®, a polycarbonate urethane. The devices have been optimized using Avastin^® as the drug of interest. In vitro biocompatibility was assessed with human lens epithelial cell (B-3), mouse macrophage (J774A.1) and mouse fibroblast (L-929) cell lines. Cell migration and proliferation were assessed after in vitro culture. Pro-inflammatory cytokines (i.e., MIP-1β, MIP-1α, MCP-1, IL-1β, TNF and TGF-β1) were quantified using cytometric bead array (CBA). Preliminary in vivo biocompatibility and pharmacokinetics testing has been performed in rabbits.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.