A New Triterpenoid from Teucrium viscidum

Molecules

Xincai Hao¹  Jinwen Zhang¹  Guangxin Xia¹  Yongbo Xue¹  Zengwei Luo¹  Yanyan Si¹  Guangmin Yao¹ 

[1] ¹Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

关键词: Teucrium viscidum;    triterpenoids;    lignans;    11β-HSD1;   

DOI  :  10.3390/molecules18011262

来源: mdpi

【 摘 要 】

A new ursane-type triterpenoid, 3β-hydroxy-urs-30-p-Z-hydroxycinnamoyloxy-12-en-28-oic-acid (1), together with three known triterpenoids, 3β-hydroxy-urs-30-p-E-hydroxycinnamoyloxy-12-en-28-oic-acid (2), 2α,3β,19α-trihydroxy-urs-12-en-28-oic-acid (3), and ursolic acid (4), four known lignans, pinoresinol (5), 9α-hydroxypinoresinol (6), (+)-medioresinol (7), and (+)-kobusin (8), and two steroids, β-sitosterol (9), and daucosterol (10), were isolated from the whole parts of Teucrium viscidum. Their structures were established by a combination of spectroscopic data analysis, besides comparison with literature data. Compounds 1–4 were evaluated for their inhibitory activities against11β-hydroxysteroid dehydrogenase 1 (11β-HSD1).

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.