Blood microRNAs in Low or No Risk Ischemic Stroke Patients

International Journal of Molecular Sciences

Jun Rong Tan²  Kay Sin Tan³  Yu Xuan Koo²  Fung Lin Yong³  Chee Woon Wang¹  Arunmozhiarasi Armugam² 

[1] Department of Biochemistry, Faculty of Medicine, MAHSA University College, 59100 Kuala Lumpur, Malaysia; E-Mail:;Department of Biochemistry and Neuroscience Research Centre, Centre for Translational Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, 117597, Singapore; E-Mails:;Department of Medicine, Faculty of Medicine, University Malaya, Kuala Lumpur 50603, Malaysia; E-Mails:

关键词: stroke;    microRNA;    etiology;    modified Rankin Score;   

DOI  :  10.3390/ijms14012072

来源: mdpi

【 摘 要 】

Ischemic stroke is a multi-factorial disease where some patients present themselves with little or no risk factors. Blood microRNA expression profiles are becoming useful in the diagnosis and prognosis of human diseases. We therefore investigated the blood microRNA profiles in young stroke patients who presented with minimal or absence of risk factors for stroke such as type 2 diabetes, dyslipidemia and hypertension. Blood microRNA profiles from these patients varied with stroke subtypes as well as different functional outcomes (based on modified Rankin Score). These microRNAs have been shown to target genes that are involved in stroke pathogenesis. The findings from our study suggest that molecular mechanisms in stroke pathogenesis involving low or no risk ischemic stroke patients could differ substantially from those with pre-existing risk factors.

【 授权许可】

CC BY   
© 2013 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.