Adhesion-Induced Phase Behavior of Two-Component Membranes and Vesicles

International Journal of Molecular Sciences

Tahereh Rouhiparkouhi¹  Thomas R. Weikl¹  Dennis E. Discher² 

[1] Theory & Bio-Systems, Max Planck Insitute of Colloids and Interfaces, Potsdam 14424, Germany; E-Mails:;Biophysical Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA; E-Mail:

关键词: lipid membranes;    phase separation;    fluid-fluid coexistence;    intramemembrane domains;    membrane adhesion;    phase diagrams;   

DOI  :  10.3390/ijms14012203

来源: mdpi

【 摘 要 】

The interplay of adhesion and phase separation is studied theoretically for two-component membranes that can phase separate into two fluid phases such as liquid-ordered and liquid-disordered phases. Many adhesion geometries provide two different environments for these membranes and then partition the membranes into two segments that differ in their composition. Examples are provided by adhering vesicles, by hole- or pore-spanning membranes, and by membranes supported by chemically patterned surfaces. Generalizing a lattice model for binary mixtures to these adhesion geometries, we show that the phase behavior of the adhering membranes depends, apart from composition and temperature, on two additional parameters, the area fraction of one membrane segment and the affinity contrast between the two segments. For the generic case of non-vanishing affinity contrast, the adhering membranes undergo two distinct phase transitions and the phase diagrams in the composition/temperature plane have a generic topology that consists of two two-phase coexistence regions separated by an intermediate one-phase region. As a consequence, phase separation and domain formation is predicted to occur separately in each of the two membrane segments but not in both segments simultaneously. Furthermore, adhesion is also predicted to suppress the phase separation process for certain regions of the phase diagrams. These generic features of the adhesion-induced phase behavior are accessible to experiment.

【 授权许可】

CC BY   
© 2013 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.