International Journal of Molecular Sciences | |
Effect of Human Flavin-Containing Monooxygenase 3 Polymorphism on the Metabolism of Aurora Kinase Inhibitors | |
Gianluca Catucci1  Andrea Occhipinti1  Massimo Maffei1  Gianfranco Gilardi1  | |
[1] Department of Life Sciences and Systems Biology, University of Torino, Via Accademia Albertina 13, Torino 10123, Italy; | |
关键词: phase I; drug metabolism; FMO3; polymorphism; enzyme kinetics; VX-680; PHA-739358; LC-MS; | |
DOI : 10.3390/ijms14022707 | |
来源: mdpi | |
【 摘 要 】
Aurora kinases were recently identified as a potential target in anticancer therapy and, amongst their available inhibitors, Tozasertib (VX-680) and Danusertib (PHA-739358) have been indicated as possible substrates of human flavin-containing monooxygenase 3 (hFMO3). Here we report the
【 授权许可】
CC BY
© 2013 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO202003190038941ZK.pdf | 392KB | download |