An Old Idea Tackling a New Problem: Targeted Toxins Specific for Cancer Stem Cells

Antibodies

Nate N. Waldron¹ 

[1] Department of Pharmacology, University of Minnesota, 210 Delaware Street Southeast Minneapolis, MN 55455, USA

关键词: cancer stem cells;    targeted toxins;    immunotoxins;    CD133;    EpCAM;    CD123;    CD44;   

DOI  :  10.3390/antib2010082

来源: mdpi

【 摘 要 】

Targeting and killing specific cells discriminately has been the goal of targeted therapy dating back to the era of Paul Ehrlich. The discovery of cancer stem cells has caused a paradigm shift within the cancer field and provided an opportunity to use targeted therapies such as targeted toxins to bind and kill these cells selectively. A number of targeted toxins have been developed against recently identified cancer stem cell markers. In this review we discuss the development and current status of these exciting novel drugs and their potential use to combat drug-refractory relapse.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.