Case Studies of the Synthesis of Bioactive Cyclodepsipeptide Natural Products

Molecules

Sara C. Stolze¹ 

[1] Zentrum für Medizinische Biotechnologie, Fakultät für Biologie, Universitätsstraße 2, 45117 Essen, Germany

关键词: cyclodepsipeptides;    total synthesis;    natural products;    apratoxin A;    spiruchostatin;    FK228;    ramoplanin;    micropeptin T-20;    Ahp-cyclodepsipeptide;    symplocamide A;   

DOI  :  10.3390/molecules18021337

来源: mdpi

【 摘 要 】

Cyclodepsipeptide natural products often display intriguing biological activities that along with their complex molecular scaffolds, makes them interesting targets for chemical synthesis. Although cyclodepsipeptides feature highly diverse chemical structures, their synthesis is often associated with similar synthetic challenges such as the establishment of a suitable macrocyclization methodology. This review therefore compiles case studies of synthetic approaches to different bioactive cyclodepsipeptide natural products, thereby illustrating obstacles of cyclodepsipeptide synthesis as well as their overcomings.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.