Two New Derivatives of 2, 5-Dihydroxyphenylacetic Acid from the Kernel of Entada phaseoloides

Molecules

Lin Chen¹  Yong Zhang¹  Gang Ding¹  Mingyu Ba¹  Ying Guo¹ 

[1] ¹Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China ²Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study(No. BZ0150), Institute of Material Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China

关键词: Entada phaseoloides;    Leguminosae;    2;    5-dihydroxyphenylacetic acid;    HIV-1;   

DOI  :  10.3390/molecules18021477

来源: mdpi

【 摘 要 】

Two new aromatic compounds, butyl 2,5-dihydroxyphenylacetate (1) and butyl 2-O-β-D-glucopyranosyloxy-5-dihydroxyphenylacetate (2), together with three known ones, methyl 2,5-dihydroxyphenylacetate (3), ethyl 2,5-dihydroxyphenylacetate (4) and2-O-β-D-glucopyranosyloxy-5-hydroxyphenylacetic acid (5), were isolated from the EtOH extract of the kernel of Entada phaseoloides. The structures of the new compounds were elucidated by MS and NMR experiments. Compounds 1, 3 and 4 displayed potent inhibitory activities against HIV-1 replication, with EC₅₀ values of 9.80 μM, 11.70 μM and 9.93 μM, respectively.

【 授权许可】

CC BY   
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