The Degradation Mechanism of Toxic Atractyloside in Herbal Medicines by Decoction

Molecules

Liang-Yu Chen¹  Anren Hu¹ 

[1] ¹Department of Biotechnology, Ming-Chuan University, Guishan, Taoyuan 333, Taiwan ²Department of Laboratory Medicine and Biotechnology, Tzu-Chi University, Hualien 970, Taiwan ³Department of Molecular Biology and Human Genetics, Tzu-Chi University, Hualien 970, Taiwan

关键词: atractyloside;    decoction;    herbal medicines;   

DOI  :  10.3390/molecules18022018

来源: mdpi

【 摘 要 】

Atractyloside (ATR) is found in many Asteraceae plants that are commonly used as medicinal herbs in China and other eastern Asian countries. ATR binds specifically to the adenine nucleotide translocator in the inner mitochondrial membrane and competitively inhibits ADP and ATP transport. The toxicity of ATR in medical herbs can be reduced by hydrothermal processing, but the mechanisms of ATR degradation are not well understood. In this study, GC-MS coupled with SPE and TMS derivatisation was used to detect ATR levels in traditional Chinese medicinal herbs. Our results suggest that ATR molecules were disrupted by decomposition, hydrolysis and saponification after heating with water (decoction) for a long period of time. Hydrothermal processing could decompose the endogenous toxic compounds and also facilitate the detoxification of raw materials used in the Chinese medicine industry.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.