Structural Requirements for the Antifungal Activities of Natural Drimane Sesquiterpenes and Analogues,Supported by Conformational and Electronic Studies

Molecules

Marcos Derita¹  Iván Montenegro¹  Francisco Garibotto¹  Ricardo D. Enriz¹  Mauricio Cuellar Fritis¹ 

[1] ¹Farmacognosia, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, 2000 Rosario, Argentina

关键词: antifungal agents;    drimanes;    structure-activity relationships;    stereo-electronic studies;   

DOI  :  10.3390/molecules18022029

来源: mdpi

【 摘 要 】

Seventeen drimanes including polygodial (1), isopolygodial (2), drimenol (3) and confertifolin (4) obtained from natural sources and the semi-synthetic derivatives 5–17 obtained from 1–3, were evaluated in vitro for antifungal properties against a unique panel of fungi with standardized procedures by using two end-points, MIC₁₀₀ and MIC₅₀. A SAR analysis of the whole series, supported by conformational and electronic studies, allowed us to show that the Δ^7,8 -double bond would be one of the key structural features related to the antifungal activity. The MEPs obtained for active compounds exhibit a clear negative minimum value (deep red zone) in the vicinity of the Δ^7,8 -double bond, which is not present in the inactive ones. Apart of this negative zone, a positive region (deep blue) appears in 1, which is not observed either in its epimer 2 nor in the rest of the active compounds. The LogP of active compounds varies between 2.33 and 3.84, but differences in MICs are not correlated with concomitant variations in LogP values.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.