Non-Enzymatic Modification of Aminophospholipids by Carbonyl-Amine Reactions

International Journal of Molecular Sciences

Alba Naudí¹  Mariona Jové¹  Victòria Ayala¹  Rosanna Cabré¹  Manuel Portero-Otín¹ 

[1] Department of Experimental Medicine, Faculty of Medicine, University of Lleida-Biomedical Research Institute of Lleida (UdL-IRBLleida), Lleida E25198, Catalonia, Spain;

关键词: advanced glycation endproducts;    advanced lipoxidation endproducts;    age-associated diseases;    aging;    cell membrane;    carbonyl compounds;    lipid peroxidation;    Maillard reaction products;    oxidative stress;    phosphatidylethanolamine;    phosphatidylserine;   

DOI  :  10.3390/ijms14023285

来源: mdpi

【 摘 要 】

Non-enzymatic modification of aminophospholipids by lipid peroxidation-derived aldehydes and reducing sugars through carbonyl-amine reactions are thought to contribute to the age-related deterioration of cellular membranes and to the pathogenesis of diabetic complications. Much evidence demonstrates the modification of aminophospholipids by glycation, glycoxidation and lipoxidation reactions. Therefore, a number of early and advanced Maillard reaction-lipid products have been detected and quantified in different biological membranes. These modifications may be accumulated during aging and diabetes, introducing changes in cell membrane physico-chemical and biological properties.

【 授权许可】

CC BY   
© 2013 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.