Increased Placental Phospholipid Levels in Pre-Eclamptic Pregnancies

International Journal of Molecular Sciences

Xiao Huang¹  Arjun Jain¹  Marc Baumann³  Meike Körner²  Daniel Surbek³  Peter Bütikofer¹ 

[1]Institute of Biochemistry and Molecular Medicine, University of Bern, Bern 3012, Switzerland

[2] E-Mails:

[3]Institute of Pathology, University of Bern, Bern 3010, Switzerland

[4] E-Mail:

[5]Swiss National Center of Competence in Research, NCCR TransCure, University of Bern, Bern 3012, Switzerland

[6] E-Mails:

关键词: phospholipids;    pre-eclampsia;    placenta;   

DOI  :  10.3390/ijms14023487

来源: mdpi

【 摘 要 】

Physiological pregnancy is associated with an increase in lipids from the first to the third trimester. This is a highly regulated response to satisfy energy and membrane demands of the developing fetus. Pregnancy disorders, such as pre-eclampsia, are associated with a dysregulation of lipid metabolism manifesting in increased maternal plasma lipid levels. In fetal placental tissue, only scarce information on the lipid profile is available, and data for gestational diseases are lacking. In the present study, we investigated the placental lipid content in control versus pre-eclamptic samples, with the focus on tissue phospholipid levels and composition. We found an increase in total phospholipid content as well as changes in individual phospholipid classes in pre-eclamptic placental tissues compared to controls. These alterations could be a source of placental pathological changes in pre-eclampsia, such as lipid peroxide insult or dysregulation of lipid transport across the syncytiotrophoblast.

【 授权许可】

CC BY   
© 2013 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.