An Efficient Chemoselective Reduction of Furan Series Unsaturated Dinitriles

Molecules

Pavel Bobal¹ 

[1] ¹Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary andPharmaceutical Sciences Brno, Palackeho 1/3, 612 42 Brno, Czech Republic ²Institute of Analytical Chemistry of the Academy of Sciences of the Czech Republic, v. v. i., Veveří 97, 602 00 Brno, Czech Republic

关键词: chemoselective reduction;    regioselective reduction;    conjugated olefins;    organic hydride compounds;    furan ethylenes;    unsaturated dinitriles;    2-phenylbenzimidazoline;   

DOI  :  10.3390/molecules18022212

来源: mdpi

【 摘 要 】

An efficient reduction of double bonds conjugated with nitrile groups and acid or base sensitive furan rings with 2-phenylbenzimidazoline generated in situ has been successfully accomplished with high yields and excellent selectivity. The employed reducing agent was prepared in one step from ordinary chemicals. The other advantages of the presented method include mild and convenient reaction conditions, a benign and cost effective reagent, simple work-up and separation of the products. As this process does neither affect cyano and nitro groups nor furan rings, it is a valuable alternative whenmetal-catalyzed hydrogenations or borohydride reductions have failed.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.