Absorption and Tensility of Bioactive Sutures Prepared for Cell Transplantation

Materials

Dénes B. Horváthy²  Gabriella Vผz²  Tamás Szabó¹  Károly Renner¹  Kinga Vajda²  Balázs Sándor² 

[1]Department of Interfaces and Surface Modification, Institute of Materials and Environmental Chemistry, Hungarian Academy of Sciences, Pusztaszeri 59-67, Budapest H-1025, Hungary

[2] E-Mails:

[3]Institute of Human Physiology and Clinical Experimental Research, Semmelweis University, Tűzoltó 37-47, Budapest H-1094, Hungary

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关键词: absorbable suture;    stem cell;    cell therapy;    tensile properties;    absorption;   

DOI  :  10.3390/ma6020544

来源: mdpi

【 摘 要 】

Biodegradable scaffolds are widely used to transplant stem cells into various tissues. Recent studies showed that living stem cells can be attached to the surface of absorbable sutures in vitro. Soaking the absorbable material polyglactin in a cell culture medium and thereby creating a stem cell biofilm on its surface may initiate the absorption process even before implantation; therefore, the physicochemical properties of the suture may be compromised in vivo. We found that pre-incubation of sutures in cell culture media in vitro results in tensile strength reduction and faster suture absorption in a rat model of muscle injury. Shorter incubation times of up to 48 h do not influence absorption or tensility; therefore, it is advisable to limit incubation times to two days for polyglactin-based cell delivery protocols.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.