Synthesis and Crystal Structures of N-Substituted Pyrazolines

Molecules

Wan-Sin Loh²  Ching Kheng Quah²  Tze Shyang Chia²  Hoong-Kun Fun²  Majal Sapnakumari¹  Badiadka Narayana¹ 

[1] Department of Studies in Chemistry, Mangalore University, Mangalagangotri-574 199, India;X-ray Crystallography Unit, School of Physics, Universiti Sains Malaysia, Penang 11800 USM, Malaysia

关键词: synthesis;    X-ray diffraction;    pyrazole;    crystal structure;   

DOI  :  10.3390/molecules18022386

来源: mdpi

【 摘 要 】

Four pyrazole compounds, 3-(4-fluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-1-carbaldehyde (1), 5-(4-bromophenyl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbaldehyde (2), 1-[5-(4-chlorophenyl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone (3) and 1-[3-(4-fluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl]propan-1-one (4), have been prepared by condensing chalcones with hydrazine hydrate in the presence of aliphatic acids, namely formic acid, acetic acid and propionic acid. The structures were characterized by X-ray single crystal structure determination. The dihedral angles formed between the pyrazole and the fluoro-substituted rings are 4.64(7)° in 1, 5.3(4)° in 2 and 4.89(6)° in 3. In 4, the corresponding angles for molecules A and molecules B are 10.53(10)° and 9.78(10)°, respectively.

【 授权许可】

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