p53 and Ceramide as Collaborators in the Stress Response

International Journal of Molecular Sciences

Rouba Hage-Sleiman¹  Maria O. Esmerian¹  Hadile Kobeissy² 

[1]Department of Pediatrics and Adolescent Medicine, Division of Pediatric Infectious Diseases, Faculty of Medicine, American University of Beirut, P.O. Box 11-0236 Riad El Solh, 1107 2020 Beirut, Lebanon

[2] E-Mails:

[3]Department of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, P.O. Box 11-0236 Riad El Solh, 1107 2020 Beirut, Lebanon

[4] E-Mail:

关键词: ceramide;    p53;    apoptosis;    sphingolipids;    mitochondria;    signaling;    Bcl2 family;    caspase;   

DOI  :  10.3390/ijms14034982

来源: mdpi

【 摘 要 】

The sphingolipid ceramide mediates various cellular processes in response to several extracellular stimuli. Some genotoxic stresses are able to induce p53-dependent ceramide accumulation leading to cell death. However, in other cases, in the absence of the tumor suppressor protein p53, apoptosis proceeds partly due to the activity of this “tumor suppressor lipid”, ceramide. In the current review, we describe ceramide and its roles in signaling pathways such as cell cycle arrest, hypoxia, hyperoxia, cell death, and cancer. In a specific manner, we are elaborating on the role of ceramide in mitochondrial apoptotic cell death signaling. Furthermore, after highlighting the role and mechanism of action of p53 in apoptosis, we review the association of ceramide and p53 with respect to apoptosis. Strikingly, the hypothesis for a direct interaction between ceramide and p53 is less favored. Recent data suggest that ceramide can act either upstream or downstream of p53 protein through posttranscriptional regulation or through many potential mediators, respectively.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.