A New 5α,8α-Epidioxysterol from the Soft Coral Sinularia gaweli

Molecules

Wei-Hsuan Yen⁵  Wu-Fu Chen⁴  Ching-Hsiao Cheng⁴  Chang-Feng Dai¹  Mei-Chin Lu⁵  Jui-Hsin Su⁵  Yin-Di Su³  Yu-Hsin Chen⁵  Yu-Chia Chang³  Yung-Husan Chen³  Jyh-Horng Sheu²  Chan-Shing Lin²  Zhi-Hong Wen² 

[1] Institute of Oceanography, National Taiwan University, Taipei 112, Taiwan; E-Mail:;Department of Marine Biotechnology and Resources and Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 833, Taiwan; E-Mails:;National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan; E-Mails:;Department of Neurosurgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan; E-Mails:;Graduate Institute of Marine Biotechnology and Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan; E-Mails:

关键词: Sinularia;    epidioxysterol;    cytotoxicity;   

DOI  :  10.3390/molecules18032895

来源: mdpi

【 摘 要 】

A new sterol, (22R,23R,24R)-5α,8α-epidioxy-22,23-methylene-24-methyl-cholest-6,9(11)-dien-3β-ol (1), and two known sterols, (22R,23R,24R)-5α,8α-epidioxy-22,23-methylene-24-methylcholest-6-en-3β-ol (2) and 24-methylenecholestane-1α,3β,5α, 6β,11α-pentol (3), were isolated from the soft coral Sinularia gaweli. The structure of sterol 1 was established by spectroscopic methods and by comparison of the spectral data with those of known analogues. The cytotoxicity of sterols 1–3 towards various tumor cells is reported.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.