Helicusin E, Isochromophilone X and Isochromophilone XI: New Chloroazaphilones Produced by the Fungus Bartalinia robillardoides Strain LF550

Marine Drugs

Nils Jansen¹  Birgit Ohlendorf¹  Arlette Erhard¹  Torsten Bruhn²  Gerhard Bringmann² 

[1] Kiel Centre for Marine Natural Products at the Helmholtz Centre for Ocean Research (GEOMAR), Kiel 24106, Germany; E-Mails:;Institute of Organic Chemistry, University of Würzburg, Am Hubland, Würzburg 97074, Germany; E-Mails:

关键词: marine natural product;    azaphilone;    pentaketide;    Bartalinia robillardoides;    Tethya aurantium;   

DOI  :  10.3390/md11030800

来源: mdpi

【 摘 要 】

Microbial studies of the Mediterranean sponge Tethya aurantium led to the isolation of the fungus Bartalinia robillardoides strain LF550. The strain produced a number of secondary metabolites belonging to the chloroazaphilones. This is the first report on the isolation of chloroazaphilones of a fungal strain belonging to the genus Bartalinia. Besides some known compounds (helicusin A (1) and deacetylsclerotiorin (2)), three new chloroazaphilones (helicusin E (3); isochromophilone X (4) and isochromophilone XI (5)) and one new pentaketide (bartanolide (6)) were isolated. The structure elucidations were based on spectroscopic analyses. All isolated compounds revealed different biological activity spectra against a test panel of four bacteria: three fungi; two tumor cell lines and two enzymes.

【 授权许可】

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© 2013 by the authors; licensee MDPI, Basel, Switzerland.