Molecules | |
Use of Mixed Micelles for Presentation of Building Blocks in a New Combinatorial Discovery Methodology: Proof-of-Concept Studies | |
Roger New1  Gurpal S. Bansal1  Michael Bogus1  Kasia Zajkowska1  Steffen Rickelt1  | |
[1] Proxima Concepts Limited, c/o London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, UK | |
关键词: mixed micelles; combinatorial biology; drug discovery; lipoamino acids; supramolecular aggregates; amphiphilic constructs; lipopetides; | |
DOI : 10.3390/molecules18033427 | |
来源: mdpi | |
【 摘 要 】
We describe a new method of combinatorial screening in which building blocks, instead of being linked together chemically, are placed on the surface of nanoparticles. Two- or three-dimensional structures form on the surface of these particles through the close approach of different building blocks, with sufficient flexibility to be able to adapt and interact with putative binding sites in biological systems. The particles assemble without the need for formation of chemical bonds, so libraries comprised of many structures can be prepared rapidly, with large quantities of material available for testing. Screening methods can include solid and solution-phase binding assays, or tissue culture models, for example looking for structures which can change the behaviour of cells in a disease-modifying manner.
【 授权许可】
CC BY
© 2013 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
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RO202003190037861ZK.pdf | 324KB | download |