Functions and Mechanisms of Fibroblast Growth Factor (FGF) Signalling in Drosophila melanogaster

International Journal of Molecular Sciences

Villö Muha¹ 

[1] Division of Cell and Developmental Biology, College of Life Sciences, University of Dundee, Dundee DD15EH, Scotland, UK; E-Mail

关键词: fibroblast growth factor;    development;    cell signalling;    cell migration;    differentiation;    Drosophila;   

DOI  :  10.3390/ijms14035920

来源: mdpi

【 摘 要 】

Intercellular signalling via growth factors plays an important role in controlling cell differentiation and cell movements during the development of multicellular animals. Fibroblast Growth Factor (FGF) signalling induces changes in cellular behaviour allowing cells in the embryo to move, to survive, to divide or to differentiate. Several examples argue that FGF signalling is used in multi-step morphogenetic processes to achieve and maintain a transitional state of the cells required for the control of cell fate. In the genetic model Drosophila melanogaster, FGF signalling via the receptor tyrosine kinases Heartless (Htl) and Breathless (Btl) is particularly well studied. These FGF receptors affect gene expression, cell shape and cell–cell interactions during mesoderm layer formation, caudal visceral muscle (CVM) formation, tracheal morphogenesis and glia differentiation. Here, we will address the current knowledge of the biological functions of FGF signalling in the fly on the tissue, at a cellular and molecular level.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.