Fibrous Polymeric Composites Based on Alginate Fibres and Fibres Made of Poly-ε-caprolactone and Dibutyryl Chitin for Use in Regenerative Medicine

Molecules

Maciej Boguń²  Izabella Krucińska²  Agnieszka Kommisarczyk²  Teresa Mikoᐪjczyk²  Marta Bᐪ៎wicz¹  Ewa Stodolak-Zych¹  El់ieta Menaszek¹ 

[1] Department of Biomaterials, Faculty of Materials Science and Ceramics, AGH University of Science and Technology, al. Mickiewicza 30, 30-059 Krakow, Poland;Department of Material and Commodity Sciences and Textile Metrology, Technical University of Lodz, ul. Żeromskiego 116, 90-924 Łódź, Poland

关键词: dibutyryl chitin;    poly-ε-caprolactone;    alginate fibres;    biodegradable polymers;   

DOI  :  10.3390/molecules18033118

来源: mdpi

【 摘 要 】

This work concerns the production of fibrous composite materials based on biodegradable polymers such as alginate, dibutyryl chitin (DBC) and poly-ε-caprolactone (PCL). For the production of fibres from these polymers, various spinning methods were used in order to obtain composite materials of different composition and structure. In the case of alginate fibres containing the nanoadditive tricalcium phosphate (TCP), the traditional method of forming fibres wet from solution was used. However in the case of the other two polymers the electrospinning method was used. Two model systems were tested for biocompatibility. The physicochemical and basic biological tests carried out show that the submicron fibres produced using PCL and DBC have good biocompatibility. The proposed hybrid systems composed of micrometric fibres (zinc and calcium alginates containing TCP) and submicron fibres (DBC and PCL) meet the requirements of regenerative medicine. The biomimetic fibre system, the presence of TCP nanoadditive, and the use of polymers with different resorption times provide a framework with specific properties on which bone cells are able to settle and proliferate.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.