Anti-Inflammatory Cycloartane-Type Saponins of Astragalus membranaceus

Molecules

Dae-Young Lee²  Hyung-Jun Noh²  Jehun Choi²  Kyeong-Hee Lee²  Min-Ho Lee¹  Ji-Hyun Lee²  Yoonpyo Hong²  Seung-Eun Lee²  Seung-Yu Kim² 

[1] Department of Food Technology and Services, Eulji University, Seongnam 461-723, Korea;Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA, Eumseong 369-873, Korea

关键词: : Astragalus membranaceus;    cycloartane-type triterpene;    agroastragaloside V;    nitric oxide;   

DOI  :  10.3390/molecules18043725

来源: mdpi

【 摘 要 】

A new cycloartane-type triterpene glycoside, agroastragaloside V (1) was isolated from the roots of Astragalus membranaceus. The structure was identified as 3-O-β-(2'-O-acetyl)-d-xylopyranosyl-6-O-β-d-glucopyranosyl-(24S)-3β,6α,24α,25-tetrahydroxy-9,19-cyclolanostane, by means of spectroscopic methods, including HR-FAB/MS, 1D NMR (¹H, ¹³C, DEPT), 2D NMR (gCOSY, gHSQC, gHMBC, NOESY), and IR spectroscopy. Four known cycloartane glycosides, namely, agroastragaloside I (2), agroastragaloside II (3), isoastragaloside II (4) and astragaloside IV (5) were also isolated. All isolated compounds were tested for the ability to inhibit LPS-induced nitric oxide production in RAW264.7 macrophages.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.