Bisucaberin B, a Linear Hydroxamate Class Siderophore from the Marine Bacterium Tenacibaculum mesophilum

Molecules

Masaki J. Fujita¹  Koji Nakano² 

[1] Creative Research Institution, Hokkaido University, Hakodate 041-8611, Japan;Graduate School of Fisheries Sciences, Hokkaido University, Hakodate 041-8611, Japan

关键词: siderophore;    Tenacibaculum mesophilum;    macrocycle;    bisucaberin;   

DOI  :  10.3390/molecules18043917

来源: mdpi

【 摘 要 】

A siderophore, named bisucaberin B, was isolated from Tenacibaculum mesophilum bacteria separated from a marine sponge collected in the Republic of Palau. Using spectroscopic and chemical methods, the structure of bisucaberin B (1) was clearly determined to be a linear dimeric hydroxamate class siderophore. Although compound 1 is an open form of the known macrocyclic dimer bisucaberin (2), and was previously described as a bacterial degradation product of desferrioxamine B (4), the present report is the first description of the de novo biosynthesis of 1. To the best of our knowledge, compound 1 is the first chemically characterized siderophore isolated from a bacterium belonging to the phylum Bacteroidetes.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.