Yellow Pigments, Fomitellanols A and B, and Drimane Sesquiterpenoids, Cryptoporic Acids P and Q, fromFomitella fraxinea and Their Inhibitory Activity againstCOX and 5-LO

Molecules

Kazuko Yoshikawa¹  Kazuaki Koso¹  Masumi Shimomura¹  Masami Tanaka¹  Hirofumi Yamamoto¹  Hiroshi Imagawa¹  Shigenobu Arihara¹ 

[1] Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho,Tokushima 770-8514, Japan

关键词: Fomitella fraxinea;    Polyporaceae;    fomitellanol;    cryptoporic acid;    cyclooxygenase-1 (COX-1) and COX-2;    5-lipoxygenase (5-LO);   

DOI  :  10.3390/molecules18044181

来源: mdpi

【 摘 要 】

Yellow pigments, fomitellanols A (1a) and B (2a), and drimane-type sesquiterpenoid ethers of isocitric acid, cryptoporic acids P (3) and Q (4), have been isolated from the fruiting bodies of Fomitella fraxinea (Polyporaceae). Their structures were established by a combination of extensive NMR spectroscopy and/or X-ray crystallographic analyses, and their biological activity against COX-1, COX-2, and 5-LO was investigated.

【 授权许可】

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