International Journal of Molecular Sciences | |
Recurrent Structural Motifs in Non-Homologous Protein Structures | |
Maria U. Johansson1  Vincent Zoete2  | |
[1] Vital-IT Group, SIB Swiss Institute of Bioinformatics, CH-1015 Lausanne, Switzerland;Molecular Modelling Group, SIB Swiss Institute of Bioinformatics, CH-1015 Lausanne, Switzerland; E-Mail: | |
关键词: Delaunay triangulation; protein fragments; long-range contacts; protein folding; protein structure; structural motifs; structure comparison/similarity; structure prediction; | |
DOI : 10.3390/ijms14047795 | |
来源: mdpi | |
【 摘 要 】
We have extracted an extensive collection of recurrent structural motifs (RSMs), which consist of sequentially non-contiguous structural motifs (4–6 residues), each of which appears with very similar conformation in three or more mutually unrelated protein structures. We find that the proteins in our set are covered to a substantial extent by the recurrent non-contiguous structural motifs, especially the helix and strand regions. Computational alanine scanning calculations indicate that the average folding free energy changes upon alanine mutation for most types of non-alanine residues are higher for amino acids that are present in recurrent structural motifs than for amino acids that are not. The non-alanine amino acids that are most common in the recurrent structural motifs,
【 授权许可】
CC BY
© 2013 by the authors; licensee MDPI, Basel, Switzerland
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO202003190037159ZK.pdf | 1183KB | download |