Effects of Antimicrobial Peptide Revealed by Simulations: Translocation, Pore Formation, Membrane Corrugation and Euler Buckling

International Journal of Molecular Sciences

Licui Chen¹  Nana Jia¹  Lianghui Gao¹  Weihai Fang¹ 

[1] Key Laboratory of Theoretical and Computational Photochemistry, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, China; E-Mails:

关键词: antimicrobial peptides;    membrane;    dissipative particle dynamics;   

DOI  :  10.3390/ijms14047932

来源: mdpi

【 摘 要 】

We explore the effects of the peripheral and transmembrane antimicrobial peptides on the lipid bilayer membrane by using the coarse grained Dissipative Particle Dynamics simulations. We study peptide/lipid membrane complexes by considering peptides with various structure, hydrophobicity and peptide/lipid interaction strength. The role of lipid/water interaction is also discussed. We discuss a rich variety of membrane morphological changes induced by peptides, such as pore formation, membrane corrugation and Euler buckling.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland