Palladium(II)-Catalyzed othro-C–H-Benzoxylation of 2-Arylpyridines by Oxidative Coupling with Aryl Acylperoxides

Molecules

Wing-Nga Sit¹  Chun-Wo Chan¹ 

[1]id="af1-molecules-18-04403">State Key Laboratory of Chirosciences and Department of Applied Biology and Chemical Technology, the Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Ko

关键词: C–H bond;    oxidation;    palladium;   

DOI  :  10.3390/molecules18044403

来源: mdpi

【 摘 要 】

A palladium(II)-catalyzed ortho-benzoxylation of 2-arylpyridines with aryl acylperoxides was developed. With pyridyl as directing group, the benzoxylation reaction exhibits remarkable regioselectivity and excellent functional group tolerance, providing the products in up to 87% yield.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.