Functionality of Fatty Acid Chemoreception: A Potential Factor in the Development of Obesity?

Nutrients

Lisa Newman¹  Rivkeh Haryono¹ 

[1] Centre for Physical Activity and Nutrition Research, School of Exercise and Nutrition Sciences, Deakin University, Burwood, Victoria 3125, Australia;

关键词: oral fatty acid chemoreception;    oral sensitivity;    fat regulation;    obesity;    BMI;    CD36;    GPCRs;   

DOI  :  10.3390/nu5041287

来源: mdpi

【 摘 要 】

Excess dietary fat consumption is recognized as a strong contributing factor in the development of overweight and obesity. Understanding why some individuals are better than others at regulating fat intake will become increasingly important and emerging associative evidence implicates attenuated fatty acid sensing in both the oral cavity and gastrointestinal (GI) tract in the development of obesity. Functional implications of impaired fatty acid chemoreception include diminished activation of the gustatory system, the cephalic response and satiety. This review will focus on knowledge from animal and human studies supporting the existence of oral fatty acid chemoreception including putative oral detection mechanisms, and how sensitivity to fatty acids is associated with fat consumption and fatty food preference.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.