The Economic Impact of Starting, Stopping, and Restarting an Antibiotic Stewardship Program: A 14-Year Experience

Antibiotics

Mary A. Ullman²  Garry L. Parlier²  James Bryan Warren²  Noe Mateo²  Craig Harvey²  Christopher J. Sullivan³  Robert Bergsbaken²  Isaac F. Mitropoulos²  John A. Bosso¹ 

[1] South Carolina College of Pharmacy, Charleston, SC 29208, USA;Regions Hospital, St. Paul, MN 55101, USA;University of Minnesota, Minneapolis, MN 55455, USA

关键词: antimicrobials;    antibiotic costs;    stewardship;    resistance;   

DOI  :  10.3390/antibiotics2020256

来源: mdpi

【 摘 要 】

Regions Hospital started a multidisciplinary antibiotic stewardship program (ASP) in 1998. The program effectively shut down from 2002–2004 as key personnel departed and was then restarted but without the dedicated pharmacist and infectious diseases physician. Purchasing data (in dollars or dollars/patient/day) unadjusted for inflation served as a surrogate marker of antibiotic consumption. These data were reviewed monthly, quarterly, and yearly along with antibiotic susceptibility patterns on a semi-annual basis. Segmented regression analysis was use to compare restricted antibiotic purchases for performance periods of 1998–2001 (construction), 2002–2004 (de-construction), and 2005–2011 (reconstruction). After 4 years (1998–2001) of operation, a number of key participants of the ASP departed. For the following three years (2002–2004) the intensity and focus of the program floundered. This trend was averted when the program was revitalized in early 2005. The construction, deconstruction, and reconstruction of our ASP provided a unique opportunity to statistically examine the financial impact of our ASP or lack thereof in the same institution. We demonstrate a significant economic impact during ASP deconstruction and reconstruction.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.