Cancers | |
Regulatory Roles for Long ncRNA and mRNA | |
Armen R. Karapetyan1  Coen Buiting1  Renske A. Kuiper1  | |
[1] Department of Human Genetics, Nijmegen Centre for Molecular Life Sciences (NCMLS), Radboud University Nijmegen Medical Centre, P.O. Box 9101, Nijmegen 6500 HB, The Netherlands; | |
关键词: non-coding RNA; epigenetic; mRNA; polycomb; remodeling; multifunctional; regulatory; transcript; lncRNA; lincRNA; | |
DOI : 10.3390/cancers5020462 | |
来源: mdpi | |
【 摘 要 】
Recent advances in high-throughput sequencing technology have identified the transcription of a much larger portion of the genome than previously anticipated. Especially in the context of cancer it has become clear that aberrant transcription of both protein-coding and long non-coding RNAs (lncRNAs) are frequent events. The current dogma of RNA function describes mRNA to be responsible for the synthesis of proteins, whereas non-coding RNA can have regulatory or epigenetic functions. However, this distinction between protein coding and regulatory ability of transcripts may not be that strict. Here, we review the increasing body of evidence for the existence of multifunctional RNAs that have both protein-coding and
【 授权许可】
CC BY
© 2013 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
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RO202003190036701ZK.pdf | 1061KB | download |