Genes | |
High SINE RNA Expression Correlates with Post-Transcriptional Downregulation of |
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Maureen Peterson2  Vicki L. Chandler1  | |
[1] Bio5 Institute, University of Arizona, Tucson Arizona, USA; E-Mail:;Department of Genetics, Geisel School of Medicine, Dartmouth College, Hanover New Hampshire, USA; E-Mail: | |
关键词:
SINE;
retrotransposon;
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DOI : 10.3390/genes4020226 | |
来源: mdpi | |
【 摘 要 】
Short Interspersed Nuclear Elements (SINEs) are non-autonomous retrotransposons that comprise a large fraction of the human genome. SINEs are demethylated in human disease, but whether SINEs become transcriptionally induced and how the resulting transcripts may affect the expression of protein coding genes is unknown. Here, we show that downregulation of the mRNA of the tumor suppressor gene
【 授权许可】
CC BY
© 2013 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
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RO202003190036627ZK.pdf | 446KB | download |