The Development of Novel Near-Infrared (NIR) Tetraarylazadipyrromethene Fluorescent Dyes

Materials

Sung-Chan Lee²  Duanting Zhai¹  Parag Mukherjee¹ 

[1] Department of Chemistry, Medicinal Chemistry Program of Life Sciences Institute, National University of Singapore, 3 Science Drive 3, 117543, Singapore; E-Mail:;Laboratory of Bioimaging Probe Development, Singapore Bioimaging Consortium, Agency for Science, Technology and Research (A*STAR), Biopolis, 138667, Singapore; E-Mail:

关键词: Near Infra-Red;    fluorescent;    aza-BODIPY;   

DOI  :  10.3390/ma6051779

来源: mdpi

【 摘 要 】

Novel structures of an near-infrared (NIR) tetraarylazadipyrromethene (aza-BODIPY) series have been prepared. We designed the core structure containing two amido groups at the para-position of the aromatic rings. The amido group was incorporated to secure insensitivity to pH and to ensure a bathochromic shift to the NIR region. Forty members of aza-BODIPY compounds were synthesized by substitution of the acetyl group with commercial amines on the alpha bromide. The physicochemical properties and photostability were investigated and the fluorescence emission maxima (745~755 nm) were found to be in the near infrared (NIR) range of fluorescence.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.