Lost in Translation: Ambiguity in Nerve Sheath Tumor Nomenclature and Its Resultant Treatment Effect

Cancers

Nicholas M. Bernthal³  Kevin B. Jones³  Michael J. Monument³  Ting Liu¹  David Viskochil² 

[1] Department of Pathology, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA;Division of Medical Genetics, Department of Pediatrics, University of Utah, Salt Lake City, UT 84112, USA;Sarcoma Services, Department of Orthopaedics, Huntsman Cancer Institute and Primary Childrens Medical Center, University of Utah, Salt Lake City, UT 84112, USA

关键词: MPNST;    neurofibromatosis;    nerve sheath tumor;    atypical neurofibroma;    low grade MPNST;   

DOI  :  10.3390/cancers5020519

来源: mdpi

【 摘 要 】

There is much ambiguity surrounding the diagnosis of nerve sheath tumors, including atypical neurofibroma and low-grade MPNST, and yet, the distinction between these entities designates either benign or malignant behavior and thus carries presumed profound prognostic importance that often guides treatment. This study reviews the diagnostic criteria used to designate atypical neurofibroma from low-grade MPNSTs and reviews existing literature the natural history of each of these tumors to see if the distinction is, in fact, of importance.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.