Melatonin Effects on Hard Tissues: Bone and Tooth

International Journal of Molecular Sciences

Jie Liu¹  Fang Huang¹ 

[1] Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou 510055, China; E-Mail:

关键词: melatonin;    bone remolding;    osteoporosis;    tooth development;    osseointegration;   

DOI  :  10.3390/ijms140510063

来源: mdpi

【 摘 要 】

Melatonin is an endogenous hormone rhythmically produced in the pineal gland under the control of the suprachiasmatic nucleus (SCN) and the light/dark cycle. This indole plays an important role in many physiological processes including circadian entrainment, blood pressure regulation, seasonal reproduction, ovarian physiology, immune function, etc. Recently, the investigation and applications of melatonin in the hard tissues bone and tooth have received great attention. Melatonin has been investigated relative to bone remolding, osteoporosis, osseointegration of dental implants and dentine formation. In the present review, we discuss the large body of published evidence and review data of melatonin effects on hard tissues, specifically, bone and tooth.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland