Plant-Derived Natural Products as Sources of Anti-Quorum Sensing Compounds

Sensors

Chong-Lek Koh²  Choon-Kook Sam²  Wai-Fong Yin¹  Li Ying Tan¹  Thiba Krishnan¹  Yee Meng Chong¹ 

[1] Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia; E-Mails:;Natural Sciences and Science Education AG, National Institute of Education, Nanyang Technological University, 1 Nanyang Walk, 637616, Singapore; E-Mails:

关键词: anti-infective;    autoinducer;    bacterial cell-to-cell communication;    biofilm;    infectious diseases;    N-acylhomoserine lactones;    pathogen;    quorum quenching;    quorum sensing;    virulence factors;   

DOI  :  10.3390/s130506217

来源: mdpi

【 摘 要 】

Quorum sensing is a system of stimuli and responses in relation to bacterial cell population density that regulates gene expression, including virulence determinants. Consequently, quorum sensing has been an attractive target for the development of novel anti-infective measures that do not rely on the use of antibiotics. Anti-quorum sensing has been a promising strategy to combat bacterial infections as it is unlikely to develop multidrug resistant pathogens since it does not impose any selection pressure. A number of anti-quorum sensing approaches have been documented and plant-based natural products have been extensively studied in this context. Plant matter is one of the major sources of chemicals in use today in various industries, ranging from the pharmaceutical, cosmetic, and food biotechnology to the textile industries. Just like animals and humans, plants are constantly exposed to bacterial infections, it is therefore logical to expect that plants have developed sophisticated of chemical mechanisms to combat pathogens. In this review, we have surveyed the various types of plant-based natural products that exhibit anti-quorum sensing properties and their anti-quorum sensing mechanisms.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.