Genome-Wide Association Study of Serum Selenium Concentrations

Nutrients

Jian Gong²  Li Hsu²  Tabitha Harrison²  Irena B. King⁷  Stefan Stürup⁶  Xiaoling Song²  David Duggan¹  Yan Liu⁹  Carolyn Hutter⁸  Stephen J. Chanock³  Charles B. Eaton⁵  James R. Marshall⁴ 

[1] Translational Genomics Research Institute, Phoenix, AZ 85004, USA; E-Mail:;Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; E-Mails:;Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA; E-Mail:;Department of Health Behavior, Roswell Park Cancer Institute, Buffalo, NY 14263, USA; E-Mail:;Center for Primary Care and Prevention, Memorial Hospital of Rhode Island, Pawtucket, RI 02860, USA; E-Mail:;Department of Pharmacy, University of Copenhagen, Copenhagen, DK-2100, Denmark; E-Mail:;Department of Internal Medicine, University of New Mexico, Albuquerque, NM 87131, USA; E-Mail:;Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD 20892, USA; E-Mail:;Stephens and Associates, Carrollton, TX 75006, USA; E-Mail:

关键词: selenium;    serum;    selenoprotein;    genome-wide association study;    AGA;    NEIL3;    SLC39A11;   

DOI  :  10.3390/nu5051706

来源: mdpi

【 摘 要 】

Selenium is an essential trace element and circulating selenium concentrations have been associated with a wide range of diseases. Candidate gene studies suggest that circulating selenium concentrations may be impacted by genetic variation; however, no study has comprehensively investigated this hypothesis. Therefore, we conducted a two-stage genome-wide association study to identify genetic variants associated with serum selenium concentrations in 1203 European descents from two cohorts: the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening and the Women’s Health Initiative (WHI). We tested association between 2,474,333 single nucleotide polymorphisms (SNPs) and serum selenium concentrations using linear regression models. In the first stage (PLCO) 41 SNPs clustered in 15 regions had p < 1 × 10⁻⁵. None of these 41 SNPs reached the significant threshold (p = 0.05/15 regions = 0.003) in the second stage (WHI). Three SNPs had p < 0.05 in the second stage (rs1395479 and rs1506807 in 4q34.3/AGA-NEIL3; and rs891684 in 17q24.3/SLC39A11) and had p between 2.62 × 10⁻⁷ and 4.04 × 10⁻⁷ in the combined analysis (PLCO + WHI). Additional studies are needed to replicate these findings. Identification of genetic variation that impacts selenium concentrations may contribute to a better understanding of which genes regulate circulating selenium concentrations.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.